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Oral glucose clearance in nonagenarians in relation to functional capacity, medication and oral variables

Identifieur interne : 009E03 ( Main/Exploration ); précédent : 009E02; suivant : 009E04

Oral glucose clearance in nonagenarians in relation to functional capacity, medication and oral variables

Auteurs : M. Lundgren [Suède] ; D. Birkhed [Suède] ; G. Steen [Suède] ; C. G. Emilson [Suède] ; T. Österberg [Suède] ; B. Steen [Suède]

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RBID : ISTEX:8726DF7248BE73ABC6D72D165923E486E2C630D6

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English descriptors

Abstract

Objectives:To study oral sugar (glucose) clearance and to examine some factors which were believed to either influence or be dependent upon oral glucose clearance. Design:Cross‐sectional, clinical study with analysis of records. Setting:Göteborg gerontological and geriatric population studies, Göteborg University, Sweden. Subjects:71 community‐dwelling individuals, 27 men and 44 women, of a representative sample of 260 92‐year‐old persons. Intervention and Main outcome measures: Glucose concentration was measured in saliva after chewing of a glucose tablet and the clearance was assessed by three different variables: (i) the initial salivary glucose concentration, (ii) the area under the curve (AUC) and (iii) the clearance time. Results:The glucose clearance showed a wide inter‐individual variation, which could be explained partly by differences in oral state, chewing time, stimulated salivary secretion rate and medication use. A positive correlation was found between the clearance variables and the number of lactobacilli and mutans streptococci in saliva and the percentage of untreated root caries lesions of the total number of exposed root surfaces. Conclusions: A slow oral sugar clearance is more common among 92‐year‐olds than younger adults earlier reported in other studies, particularly in those who have uncompensated functional impairments and a high medication history. A decreased oral glucose clearance was associated with high counts of salivary lactobacilli and mutans streptococci and a high proportion of untreated root caries lesions.

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DOI: 10.1111/j.1741-2358.1997.00017.x


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Le document en format XML

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<term>Caries</term>
<term>Clearance</term>
<term>Clearance time</term>
<term>Clearance variables</term>
<term>Column trend</term>
<term>Coordination ability</term>
<term>Correlation coefficients</term>
<term>Dent</term>
<term>Dental plaque</term>
<term>Dental state</term>
<term>Dentate subjects</term>
<term>Denture</term>
<term>Denture wearers</term>
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<term>Drug statistics methodology</term>
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<term>Drug variables</term>
<term>Elderly people</term>
<term>Elderly persons</term>
<term>Figures show</term>
<term>Flow rate</term>
<term>Functional capacity</term>
<term>Geriatric population studies</term>
<term>Glucose</term>
<term>Glucose clearance</term>
<term>Glucose concentration</term>
<term>Glucose concentrations</term>
<term>Glucose tablet</term>
<term>Goteborg</term>
<term>Goteborg gerontological</term>
<term>Goteborg university</term>
<term>High counts</term>
<term>High proportion</term>
<term>Hypnotic</term>
<term>Initial concentration</term>
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<term>Lactobacillus</term>
<term>Linear regression</term>
<term>Maximum assembly time</term>
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<term>Mutans streptococci</term>
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<term>Oral biol</term>
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<term>Oral sugar clearance</term>
<term>Oral variables</term>
<term>Other studies</term>
<term>Perceptual ability</term>
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<term>Plaque score</term>
<term>Positive correlation</term>
<term>Present study</term>
<term>Psychoactive drugs</term>
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<term>Regression line</term>
<term>Root caries</term>
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<term>Salivary clearance</term>
<term>Salivary flow rate</term>
<term>Salivary glucose clearance</term>
<term>Salivary glucose clearance time</term>
<term>Salivary glucose concentrations</term>
<term>Salivary lactobacilli</term>
<term>Salivary secretion rate</term>
<term>Secretion</term>
<term>Secretion rate</term>
<term>Sedative</term>
<term>Significant correlation</term>
<term>Significant differences</term>
<term>Streptococci</term>
<term>Sugar clearance</term>
<term>Swenander lanke</term>
<term>Tablet intake</term>
<term>Test pieces</term>
<term>Total number</term>
<term>Total proportions</term>
<term>Typical morphology</term>
<term>Untreated root caries lesions</term>
<term>Wide variation</term>
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<term>Cardiovascular</term>
<term>Cardiovascular agents</term>
<term>Caries</term>
<term>Clearance</term>
<term>Clearance time</term>
<term>Clearance variables</term>
<term>Column trend</term>
<term>Coordination ability</term>
<term>Correlation coefficients</term>
<term>Dent</term>
<term>Dental plaque</term>
<term>Dental state</term>
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<term>Denture wearers</term>
<term>Diuretic</term>
<term>Drug statistics methodology</term>
<term>Drug treatment</term>
<term>Drug variables</term>
<term>Elderly people</term>
<term>Elderly persons</term>
<term>Figures show</term>
<term>Flow rate</term>
<term>Functional capacity</term>
<term>Geriatric population studies</term>
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<term>Glucose clearance</term>
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<term>Goteborg</term>
<term>Goteborg gerontological</term>
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<term>Secretion rate</term>
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<front>
<div type="abstract">Objectives:To study oral sugar (glucose) clearance and to examine some factors which were believed to either influence or be dependent upon oral glucose clearance. Design:Cross‐sectional, clinical study with analysis of records. Setting:Göteborg gerontological and geriatric population studies, Göteborg University, Sweden. Subjects:71 community‐dwelling individuals, 27 men and 44 women, of a representative sample of 260 92‐year‐old persons. Intervention and Main outcome measures: Glucose concentration was measured in saliva after chewing of a glucose tablet and the clearance was assessed by three different variables: (i) the initial salivary glucose concentration, (ii) the area under the curve (AUC) and (iii) the clearance time. Results:The glucose clearance showed a wide inter‐individual variation, which could be explained partly by differences in oral state, chewing time, stimulated salivary secretion rate and medication use. A positive correlation was found between the clearance variables and the number of lactobacilli and mutans streptococci in saliva and the percentage of untreated root caries lesions of the total number of exposed root surfaces. Conclusions: A slow oral sugar clearance is more common among 92‐year‐olds than younger adults earlier reported in other studies, particularly in those who have uncompensated functional impairments and a high medication history. A decreased oral glucose clearance was associated with high counts of salivary lactobacilli and mutans streptococci and a high proportion of untreated root caries lesions.</div>
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